Greater Houston Psychiatric Associates would like to introduce to our patients Spravato® therapy as a potential treatment option for depression. Spravato® therapy is an FDA-approved nasal spray that contains esketamine, a chemical similar to the anesthetic ketamine. This therapy has been shown to be effective in treating adults with treatment-resistant depression who have not responded well to other forms of antidepressant medication. Spravato® therapy is typically used in combination with an oral antidepressant and is administered under the supervision of a healthcare professional in a clinical setting.

What is SPRAVATO®?
  •     • SPRAVATO® is the first FDA-approved nasal spray medication, taken with an oral antidepressant, for Adults with treatment-resistant depression (TRD) Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions.
  •     • If taking Spravato®, do not drive, operate machinery, or do anything where you need to be completely alert after a treatment session. You will not be able to drive, so plan transportation for treatment days.
  •     • You will administer the nasal spray yourself under the supervision of a healthcare provider. You'll be monitored for side effects for at least 2 hours after taking SPRAVATO®. Your healthcare provider will decide when you are ready to leave the healthcare setting.
  •     • You should tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Taking SPRAVATO® with certain medicine may cause side effects. Especially tell your healthcare provider if you take central nervous system (CNS) depressants, psychostimulants, or monoamine oxidase inhibitors (MAOIs) medicines.
  •     • Because of the risks for sedation, dissociation and abuse and misuse, SPRAVATO® is only available through a restricted program called the SPRAVATO ® Risk Evaluation and Mitigation Strategy (REMS) Program.

Getting started

Greater Houston Psychiatric Associates is a certified SPRAVATO® REMS treatment center. Spravato®/ Esketamine Nasal Spray is a treatment that involves the administration of Spravato®/ Esketamine by a nasal spray under the direct supervision of a trained mental health care provied followed by a 2 hour monitoring period in a healthcare setting. This required monitoring is part of the Spravato® REMS program due to the potential serious side effects including sedation, possible dissociation and misuse of abuse.

For more information or to schedule an assessment, call our Spravato® Coordinator, 713-346-1548.

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What to expect during Spravato® treatment